Distribution of patients with anti-FLRT2 activity. (A) The distribution of anti-FLRT2 activity in collagen diseases was measured with flow cytometry. Dots represent the data for individual subjects. The broken horizontal line indicates the cutoff value for high anti-FLRT2 activity (mean + 3SD). Collagen diseases included systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjögren syndrome (SS), polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), rheumatoid arthritis (RA), polyarteritis nodosa (PN), Churg-Strauss syndrome (CSS), microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and Takayasu arteritis (TA). (B) Correlations of clinical parameters with anti-FLRT2 activity among anti-FLRT2-positive SLE patients are shown. CH50, 50% hemolytic complement activity; SLEDAI, SLE disease activity index; dsDNA Ab, anti-double-stranded DNA antibody; SAA, serum amyloid A.
Shirai et al. Arthritis Research & Therapy 2012 14:R157 doi:10.1186/ar3897