Gene expression of IL-1β in PBMCs from gout patients stimulated with MSU and Pam3Cys compared with healthy controls. Measurement of mRNA transcripts of IL-1β after stimulation of PBMCs of patients with gout and controls with FFA C18:0 (A) or Pam3Cys (B) alone or in combination with monosodium urate (MSU) crystals. Results are shown as ratios with the transcripts of β2- microglobulin. Gout patients n = 8 and healthy controls n = 6. FFA, free fatty acids; MSU, monosodium urate monohydrate; Pam3Cys, Pam3Cys, palmitoyl-3-cystein; PBMC, peripheral blood mononuclear cells.
Mylona et al. Arthritis Research & Therapy 2012 14:R158 doi:10.1186/ar3898