Histological analyses of knee joints. Fifty percent of the mice treated with vehicle control, syngeneic or partially mismatched MSCs had erosive disease compared to 70% of those treated with fully mismatched MSCs. A, B, A normal knee joint is illustrated (scale bar 500 μm and 125 μm, respectively). C, D, Synovial hypertrophy with erosive disease in the knee joint (black arrow) (scale bar 500 μm and 125 μm, respectively). E, A control interphalangeal joint (IPJ) of the paw (500 μm), F, IPJ with synovial hypertrophy and early erosive disease (black arrow) (500 μm) and G, a severely diseased IPJ with synovial hypertrophy and extensive erosive disease (black arrows); scale bars, 500 μm. MSC, mesenchymal stem cells.
Sullivan et al. Arthritis Research & Therapy 2012 14:R167 doi:10.1186/ar3916