Lymphocytic infiltrates in the salivary glands. Representative images for hematoxylin and eosin (H&E) and CD3/B220 staining for saline-, rAAV2-LacZ-, and rAAV2-IL27-treated groups at 20 weeks after gene delivery in pre-disease and clinical disease groups. H&E images were taken at ×6 magnification and immunofluorescence staining images of lymphocytic infiltrates with anti-CD3 to detect T cells (green) and anti-B220 to detect B cells (red) were taken at ×100 magnification with a Zeiss Axiovert 200 M microscope. IL-27, rAAV2-IL27-treated groups; LacZ, rAAV2-LacZ-treated groups; Saline, saline-treated groups.
Lee et al. Arthritis Research & Therapy 2012 14:R172 doi:10.1186/ar3925