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Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis

Petya Dimitrova1*, Nina Ivanovska1, Lyudmila Belenska1, Viktoriya Milanova1, Wilhelm Schwaeble2 and Cordula Stover2

Author Affiliations

1 Department of Immunology, Institute of Microbiology, 26 Georgi Bonchev St., Sofia, 1113, Bulgaria

2 Department of Infection, Immunity and Inflammation, University of Leicester, Maurice Shock Medical Sciences Building, University Road, Leicester, LE1 9HN, UK

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Arthritis Research & Therapy 2012, 14:R173  doi:10.1186/ar3926

Published: 25 July 2012

Additional files

Additional file 1:

FcγR expression on synovial and blood neutrophils and on monocytes in properdin-deficient mice with CAIA. (A) FcγR was expressed on blood wild-type Ly6G+ cells but not on properdin-deficient cells, as shown in one individual experiment. Frequencies of Ly6G+ FcγR+ in blood at day 10 of disease are presented on the graph. Data are expressed as the mean ± SD of the positive cells from three experiments involving four mice/group; *P < 0.05; ***P < 0.001; Student t test. (B) Elevated numbers of CD14+ FcγR+ cells in blood of KO CAIA mice are shown on the graph. Data represent the mean ± SD of positive cells from three experiments involving five mice/group. *P < 0.05; **P < 0.01; and ***P < 0.001; Student t test. (C) FcγR expression was found on synovial neutrophils from arthritic properdin-deficient and wild-type mice. The histograms are representative of three separate experiments and show the analyses of the synovial cell pool from five mice/group.

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