High mobility group box 1 (HMGB1) concentrations in serum and urine from SLE patients with active lupus nephritis (LN), patients without active LN but with a history of LN, patients without history of LN, and healthy controls (HC). (A) Serum HMGB1 levels. (B) Urine HMGB1 levels. (C) Urine HMGB1 levels corrected for urine creatinine levels. Horizontal lines represent the median. (D) Representative blots for urine HMGB1 measurement; lane 1: molecular weight marker, lanes 2, and 18: positive control, lanes 3, 5, 7, 9, 11, 13, and 15: urine samples of SLE patients, lane 17: urine of HC.
Abdulahad et al. Arthritis Research & Therapy 2012 14:R184 doi:10.1186/ar4015