Correlation between in vitro and in vivo glucocorticoid sensitivity in intramuscularly treated RA patients. In vivo glucocorticoid sensitivity is presented as percentage improvement in DAS according to the following formula:
Correlations between √IL-2-EC50 values (A), GILZ-EC50 values (B), natural logarithm of the number of GRs per cell (C), and natural logarithm of the KD of the receptor (D) and percentage improvement DAS. R2, square of the Pearson correlation coefficient; proportion explained variability. Triangles (▲) represent the tREACH patients, and solid circles (●) represent FLARE patients.
Quax et al. Arthritis Research & Therapy 2012 14:R195 doi:10.1186/ar4029