Protein-protein interaction network of chondroitin sulfate effects. The STRING database was searched for protein interaction analyses in order to elucidate the effect of chondroitin sulfate on cartilage extracellular matrix (ECM) proteins. As shown, most of the altered proteins interact with each other to constitute a large network. These proteins are involved in several processes, but essentially belong to immune response, inflammation and ECM remodeling pathways.
Calamia et al. Arthritis Research & Therapy 2012 14:R202 doi:10.1186/ar4040