ColX, IGFBP-3, and HMGA1 mRNA levels in osteoarthritis. ColX (left), IGFBP-3 (center), and HMGA1 (right) mRNA expression in human chondrocytes from healthy donors (black columns) and from patients with osteoarthritis (gray columns), as measured by quantitative real-time reverse transcription-polymerase chain reaction of total RNA. Columns indicate mean values; error bars denote standard deviation. *P < 0.0001; **P = 0.0045; ***P = 0.0022. ColX, type X collagen; HMGA1, high-mobility group A1; IGFBP-3, insulin-like growth factor binding protein 3.
Gasparini et al. Arthritis Research & Therapy 2012 14:R207 doi:10.1186/ar4045