TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation
1 Department of Pathology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea
2 Laboratory of Immune Regulation in Department of Biomedical Sciences, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea
Arthritis Research & Therapy 2012, 14:R210 doi:10.1186/ar4048Published: 4 October 2012
Additional file 1:
Subset analysis for joint cells from mice with antibody-induced arthritis. Total joint cells were obtained from WT mice seven days after K/BxN serum transfer and analyzed for cell subsets. (A) Total cells were stained using anti-CD45.2 mAb as compared with isotype-matched control. (B) Subset analysis for total joint cells was performed.
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