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Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

Darren Plant1, Ibrahim Ibrahim1, Mark Lunt1, Stephen Eyre1, Edward Flynn1, Kimme L Hyrich1, Ann W Morgan23, Anthony G Wilson4, John D Isaacs5, BRAGGGSS6 and Anne Barton17*

Author Affiliations

1 Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Science, University of Manchester, Oxford Road, Manchester, M13 9PT, UK

2 NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, The Leeds Teaching Hospitals NHS Trust, Chapeltown Road, Leeds, LS7 4SA, UK

3 Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, The Leeds Teaching Hospitals NHS Trust, Beckett Street, Leeds, LS9 7TF, UK

4 Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK

5 Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK

6 Member details at end of article

7 NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Grafton Street, Manchester, M13 9WL, UK

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Arthritis Research & Therapy 2012, 14:R214  doi:10.1186/ar4052

Published: 7 October 2012

Additional files

Additional file 1:

Histogram and box-and-whisker plot of CRP levels. (A) Histogram showing raw distribution of CRP levels in individuals (n = 599) included in analyses. (B) Box-and-whisker plot showing median baseline CRP level and interquartile range of individuals (n = 599) included in analyses.

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