Percentage changes in bone mineral density (BMD) of the radius measured by dual-energy x-ray absorptiometry (DXA) at 6, 12 and 18 months after the start of treatment in the Bisphosphonate (Bis) and Bis + statin groups. Circles represent the Bis group and triangles represent the Bis + statin group. Significant decreases in BMD of the radius were observed at 12 and 18 months in the Bis group. In the Bis + statin group, a significant decrease was only observed at 6 months, and after 6 months tended to increase at 12 and 18 months. *P < 0.05, **P < 0.01, for comparison to baseline for each group.
Nagashima et al. Arthritis Research & Therapy 2012 14:R224 doi:10.1186/ar4063