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Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis

Rowan Hardy1, Maria Juarez2, Amy Naylor2, Jinwen Tu3, Elizabeth H Rabbitt1, Andrew Filer2, Paul M Stewart1, Christopher D Buckley24, Karim Raza24 and Mark S Cooper1*

Author Affiliations

1 Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK

2 Rheumatology Research Group, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TH, UK

3 Bone Research Program, ANZAC Research Institute, 1A Hospital Road, Concord, Sydney NSW 2139, Australia

4 Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, City Hospital, Dudley Road, Birmingham, B18 7QH, UK

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Arthritis Research & Therapy 2012, 14:R226  doi:10.1186/ar4065

Published: 18 October 2012

Additional files

Additional file 1:

Table S1. Complete list of genes included in array: Complete list of genes included in array examining the impact of TNFα and glucocorticoid treatments on Wnts, Wnt inhibitors and Wnt-regulated genes. Shaded rows indicates genes where expression was significantly impacted on by either TNFα or dexamethasone (DEX). Array data have been submitted to the Gene Expression Omnibus (GEO) repository and given the designation GSE37520.

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