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Highly Accessed Open Badges Editorial

Imaging joints for calcium pyrophosphate crystal deposition: a knock to the knees

Robert Terkeltaub

Author Affiliations

Rheumatology Section, San Diego Veterans Affairs Medical Center, Division of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA

Arthritis Research & Therapy 2012, 14:128  doi:10.1186/ar4097

See related research by Abhishek et al.,

Published: 27 December 2012


With advanced age, articular calcium pyrophosphate crystal deposition (CPPD) is common. Defining who has CPPD is of growing importance, given increases in longevity in many countries and the frequent association of chondrocalcinosis with osteoarthritis. Chondrocalcinosis detected by plain radiography serves as a major screening tool, but how many and which sites to screen have not been adequately defined in the past. The work of Abhishek and colleagues in the previous issue of Arthritis Research and Therapy sheds new light on the incomplete information from knee radiographs, and helps position us to learn more about the epidemiology, pathophysiology, diagnosis, and clinical impact of CPPD.