T cells in myositis
Rheumatology Unit, Dept of Medicine, L8:04, Karolinska Institutet, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden
Arthritis Research & Therapy 2012, 14:230 doi:10.1186/ar4116Published: 28 December 2012
T cells of both the CD4 and CD8 lineage are commonly found in affected tissues of patients with idiopathic inflammatory myopathies, but understanding the contribution of these cells to immunopathogenesis remains challenging. Given recent advances in identifying more myositis-associated autoantibodies and their putative targets, we suggest that studies on autoreactive T cells targeting those autoantigens are one way forward. Another (so far, more frequently used) approach comes from studies on effector T cells in the context of myositis. This review summarizes recent advances and current hypotheses in both of these contexts.