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Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis

Chun Lai Too12*, Shahnaz Murad2, Jasbir Singh Dhaliwal2, Per Larsson3, Xia Jiang4, Bo Ding4, Lars Alfredsson4, Lars Klareskog1 and Leonid Padyukov1

Author Affiliations

1 Rheumatology Unit, Department of Medicine, Karolinska University Hospital, CMM L8:04, S-171 76 Stockholm, Sweden

2 Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia

3 Department of Rheumatology, R 92, Karolinska University Hospital Huddinge, S-171 76 Stockholm, Sweden

4 Institute of Environmental Medicine, Karolinska Institutet, Nobel väg 13, Box 210, S-171 77 Stockholm, Sweden

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Arthritis Research & Therapy 2012, 14:R250  doi:10.1186/ar4093

Published: 19 November 2012

Additional files

Additional file 1:

Table S1 presenting a list of PADI SNPs investigated in the MyEIRA study population. A complete set of 320 SNPs selected from the PADI locus on Immunochip and from other studies. The SNPs were genotyped either using the TaqMan SNP genotyping assay (Applied Biosystems, USA) or by Illumina iSELECT HD custom genotyping array (Immunochip). Table S2 presenting the haplotype frequencies and meta-analysis of PADI4 polymorphisms in the MyEIRA study by ACPA status. The haplotype analysis and meta-analysis of PADI4 polymorphisms in the MyEIRA study were performed in different subsets of RA defined by ACPA status. Bold results indicate significant association between the PADI haplotypes and subsets of RA. Figure S1 showing the regional association plots with recombination rate on the PADI genes for the three major ethnic groups from the MyEIRA study. Regional association plots on the PADI genes including PADI1, PADI2, PADI3, PADI4 and PADI6 for the three major ethnic groups from MyEIRA study showing the peak association in each ethnic group. Graphs centered on the most significant SNP in each ethnic group. The r2 values (linkage disequilibrium between the most significant SNP and the rest of SNPs in the region) are calculated on the MyEIRA data and the recombination rates are based on the International HapMap CHB+JPT data.

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