The effects of Fn and cFn on the apoptosis of FLSs isolated from RA or OA patients. The isolated FLSs from RA and OA patients were treated for 72 h as indicated and the apoptosis was detected by Annexin V-FITC/PI (A) and TUNEL analysis (B). RA (n = 8) and OA (n = 6) * P < 0.05, ** P < 0.01, and NS, not significant. cFn, citrullinated fibronectin; FITC, fluorescein isothiocyanate; FLSs, fibroblast-like synoviocytes; Fn, fibronectin; OA, osteoarthritis; PI, propidium iodide; RA, rheumatoid arthritis; TUNEL, terminal deoxyribonucleotidyl transferase mediated dUTP nick-end labeling.
Fan et al. Arthritis Research & Therapy 2012 14:R266 doi:10.1186/ar4112