The effects of Fn and cFn on the expression of apoptosis-related molecules in FLSs isolated from RA or OA patients. RA or OA FLSs were treated with Fn or cFn at 2 μg/ml for 72 h and total RNA was isolated for the analysis of survivin, caspase 3, cyclin-B1, Bcl-2 and Bax mRNA levels. RA (n = 8) and OA (n = 6). * P < 0.05 compared with blank, ** P < 0.01 compared with blank. Δ P < 0.05 compared with cFn, ΔΔ P < 0.01 compared with cFn. cFn, citrullinated fibronectin; FLSs, fibroblast-like synoviocytes; Fn, fibronectin; OA, osteoarthritis; RA, rheumatoid arthritis.
Fan et al. Arthritis Research & Therapy 2012 14:R266 doi:10.1186/ar4112