Skip to main content
  • Poster presentation
  • Open access
  • Published:

Intermittent cold stress-induced experimental fibromyalgia model in mice - pharmacology and neurobiology

Stress-induced pain, as in Fibromyalgia (FM), is considered to be caused by intense events involving physical and psychological injury and is reinforced by successive stress. Previously, we have established a novel mice model of FM, using intermittent cold stress (ICS) exposure. Mice given ICS caused abnormal pain, including mechanical allodynia and hyperalgesia to nociceptive thermal and chemical stimuli, which lasted for more than 2 weeks. In contrast, those given constant cold stress (CCS) did not. The abnormal pain was generalized, female-predominant and specific for A-delta and A-beta, but not C-fiber-stimuli in the electrical stimulation-induced nociceptive test. The mechanical allodynia induced by ICS was effectively suppressed by intraperitoneal or intracerebroventricular injection of gabapentin. The potency and duration of anti-allodynia effects were much higher and longer, respectively, than the neuropathic pain induced by sciatic nerve injury. Taken together, these findings indicate that mice given ICS manifest most of characteristics observed in fibromyalgia patients in terms of pharmacology and pain physiology.

References

  1. Nishiyori M, Ueda H: Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia. Mol Pain. 2008, 4: 52-10.1186/1744-8069-4-52.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Nishiyori M, Nagai J, Nakazawa T, Ueda H: Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia. Neurosci Lett. 2010, 472: 184-187. 10.1016/j.neulet.2010.01.080.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The research described in this article was supported in part by MEXT KAKENHI (17109015 to Hiroshi Ueda) and Health Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare of Japan (to Hiroshi Ueda): "Research on Allergic disease and Immunology" also supported this work.

Author information

Authors and Affiliations

Authors

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Cite this article

Araki, K., Nishiyori, M. & Ueda, H. Intermittent cold stress-induced experimental fibromyalgia model in mice - pharmacology and neurobiology. Arthritis Res Ther 14 (Suppl 1), P6 (2012). https://doi.org/10.1186/ar3607

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/ar3607

Keywords