Baseline circulating osteopontin levels correlated with disease-related damage accumulated over the subsequent twelve months. Mean baseline natural log-transformed circulating osteopontin (lncOPN) was higher in pediatric- and adult-onset systemic lupus erythematosus (pSLE and aSLE) patients who had an increase in (SDI) scores over the 12-month study period (left), but not mean natural log-transformed circulating neutrophil gelatinase-associated lipocalin (lncNGAL) (right). SDI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index.
Rullo et al. Arthritis Research & Therapy 2013 15:R18 doi:10.1186/ar4150