Relative gene expression of relevant target genes. Relative gene expression of Brachyury, Cytokeratin 8, Axin2, Frizzled 1 (Fzd1), Low density lipoprotein receptor-related protein 5 (Lrp5), Wnt7b, Wnt inhibitory factor 1 (Wif1), Integrin linked kinase (Ilk), and Dickkopf homolog 3 (Dkk3) in the notochordal cell-rich (NC-rich), mixed, and chondrocyte-like cell rich (CLC-rich) NP from non-chondrodystrophic (NCD) and chondrodystrophic (CD) dogs (NCD, NC-rich NP was used as reference, set at 1). *Significant difference between NC-rich, mixed, and CLC-rich NP; §significant difference between NCD and CD dogs.
Smolders et al. Arthritis Research & Therapy 2013 15:R23 doi:10.1186/ar4157