Pedigrees of four families with NLRP3 V198M. Family 1 with three members affected by MWS/FCAS/CINCA, family 2 with a proband diagnosed with familial cold autoinflammatory syndrome (FCAS), family 3 with a proband affected by Schnitzler syndrome and family 4 with a proband affected by uncharacterized long-standing systemic inflammatory disorder. Open shapes represent healthy individuals, solid shapes represent affected individuals, and shaded shapes represent asymptomatic carriers; each proband is indicated by an arrow.
Rowczenio et al. Arthritis Research & Therapy 2013 15:R30 doi:10.1186/ar4171