Figure 1.

Synthesis of [18F]fluoro-PEG-folate. Synthesis of [18F]fluoro-PEG-folate. Conditions: i: [18F]fluoride, acetonitrile, K[2.2.2], K2CO3, 90°C, 10 minutes; ii: a: tetrapropylammonium hydroxide, b: tetramethyl-o-(N-succinimidyl)uranium tetrafluoroborate, 30 to 50% (for i and ii); iii: 150 mM borate buffer, 30 minutes ambient temperature, 70 to 90%.

Gent et al. Arthritis Research & Therapy 2013 15:R37   doi:10.1186/ar4191
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