Transcript and protein levels of Toll-like receptor (TLR)7 signaling molecules in patients with adult-onset Still's disease (AOSD), patients with systemic lupus erythematosus (SLE), and healthy volunteers. The comparison in transcript levels of TLR7 signaling molecules, including TLR7 (A), Myeloid differentiation primary-response protein 88 (MyD88) (B), IL-1 receptor-associated kinase (IRAK)4 (C), TNF receptor-associated factor (TRAF)6 (D), IFN regulatory factor (IRF)5 (E), and IFN-α (F) among AOSD patients, SLE patients, and healthy controls (HCs). The horizontal line indicates median value for each group. Immunoblot analyses (G) for protein expression of TLR7 signaling molecules in the lysates of peripheral blood samples from six AOSD patients, three SLE patients and three healthy volunteers. The comparison in the protein expression levels of TLR7 signaling molecules among three groups (H). Bars show the mean ± standard error of the mean; *P <0.05 versus healthy controls (Mann-Whitney U-test).
Chen et al. Arthritis Research & Therapy 2013 15:R39 doi:10.1186/ar4193