Progression of joint damage in the radiolunate joint. Magnetic resonance imaging (MRI) of the wrist shows thin but present high-signal-intensity cartilage over articular surfaces of the radiolunate joint (large arrow) at baseline (A) associated with grade-1.0 cartilage thinning. Corresponding baseline conventional radiography (XR) (D) shows joint-space narrowing (JSN) at this location (large arrow). Follow-up MRI at 12 weeks (B) and 24 weeks (C) show progressive JSN associated with loss of cartilage over both articular surfaces of this joint, indicative of grade-3.0 cartilage loss. Note development and progression of bone erosions (small arrows) in the radius and lunate on these follow-up scans. Week-24 XR also shows complete radiolunate JSN, the lunate erosion and two of the radius erosions (small arrows). However, the third erosion in the radius is not visible on XR.
Peterfy et al. Arthritis Research & Therapy 2013 15:R44 doi:10.1186/ar4202