Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara
- Equal contributors
1 Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Sierra Mojada 950, Planta baja, Edificio P Ala oriente, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, CP 44340 Mexico
2 Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610-0221, USA
3 Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610-0221, USA
4 Direction of Education and Research, Hospital de Especialidades Centro Médico La Raza, IMSS, Calzada Vallejo y Jacarandas S/N, Mexico City, CP 02990, Mexico
5 Servicio de Reumatología, Hospital La Raza, IMSS, Cd. de México, Calzada Vallejo y Jacarandas S/N, CP 02990, Mexico
6 Centro Médico Nacional 20 de Noviembre, ISSSTE, Felix Cuevas 540 Del Valle 03100, D.F., México
7 División de Medicina Interna, Hospital La Raza, IMSS, Cd de México, Calzada Vallejo y Jacarandas S/N, CP 02990, Mexico
8 División de Investigación, CMNO, IMSS, Departamento de Fisiología del Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Av. Belisario Domínguez 1000, SL. Guadalajara, JL 44349, Mexico
9 Servicio de Reumatología, CMNO, IMSS, Av. Belisario Dominguez 1000, Guadalajara, JL 44349, Mexico
10 Servicio de Medicina Interna Reumatología, Hospital General Regional 110, IMSS, Prolongacion Circunvalacion Oblatos 2208 Guadalajara, Jalisco, CP 44700, Mexico
11 UMAE, CMNO, IMSS, Guadalajara, Guadalajara, Jalisco, Av. Belisario Dominguez 1000, CP 44349, Mexico
12 Instituto de astronomia y Meteorologia, Departamento de Fisica. Division de Ciencias Basicas, Universidad de Guadalajara, Av. Vallarta 2602, CP44130, Mexico
13 Department of Oral Biology, University of Florida, Gainesville, FL 32610-0221, USA
14 División de Medicina Interna, Servicio de Reumatología, Hospital Civil Dr. Juan I. Menchaca, Guadalajara, Jalisco, Salvador Quevedo y Zubieta S/N, CP 44240, Mexico
Arthritis Research & Therapy 2013, 15:R48 doi:10.1186/ar4207Published: 4 April 2013
Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic and environmental factors. The high prevalence of DM and anti-Mi-2 in Central America is thought to be associated with the high UV index of the area. The prevalences of autoantibodies and the clinical manifestations of PM/DM were evaluated comparing two cohorts in Mexico.
Ninety-five Mexican patients with PM/DM (66 DM, 29 PM; 67 Mexico City, 28 Guadalajara) were studied. Autoantibodies were characterized by immunoprecipitation using 35S-methionine labeled K562 cell extract. Clinical information was obtained from medical records.
DM represented 69% of PM/DM and anti-Mi-2 was the most common autoantibody (35%), followed by anti-p155/140 (11%); however, anti-Jo-1 was only 4%. The autoantibody profile in adult-onset DM in Mexico City versus Guadalajara showed striking differences: anti-Mi-2 was 59% versus 12% (P = 0.0012) whereas anti-p155/140 was 9% versus 35% (P = 0.02), respectively. A strong association of anti-Mi-2 with DM was confirmed and when clinical features of anti-Mi-2 (+) DM (n = 30) versus anti-Mi-2 (-) DM (n = 36) were compared, the shawl sign (86% versus 64%, P < 0.05) was more common in the anti-Mi-2 (+) group (P = 0.0001). Levels of creatine phosphokinase (CPK) were higher in those who were anti-Mi-2 (+) but they responded well to therapy.
Anti-Mi-2 has a high prevalence in Mexican DM and is associated with the shawl sign and high CPK. The prevalence of anti-Mi-2 and anti-p155/140 was significantly different in Mexico City versus Guadalajara, which have a similar UV index. This suggests roles of factors other than UV in anti-Mi-2 antibody production.