TGF-β1 secretion is decreased by A2AR activation at earlier time points and restored after 24 hours. NHDF cells were serum-starved and incubated with CGS-26180 1 µM at the indicated time periods and released TGF-β1 levels were analyzed by ELISA. Data represent means ± S.E.M. from four independent experiments. Statistics were performed by unpaired-t test, ***P <0.001, **P <0.01, vs. non-stimulated control.
Chan et al. Arthritis Research & Therapy 2013 15:R58 doi:10.1186/ar4229