Comparison of IL-21R-expressing B-cells from patients with granulomatosis with polyangiitis (GPA) and healthy controls (HCs). (A) Representative fluoresence-activated cell sorting (FACS) plots of IL-21R expression on CD19+ B-cells from an antineutrophil cytoplasmic antibody (ANCA)-negative (right plot) and an ANCA-positive (middle plot) GPA patient, and an age- and sex-matched HC (left plot). Values in each gate represent the percentages of IL-21R+ B-cells. (B) The percentage of IL-21R+ B-cells was determined in peripheral blood from ANCA-positive (n = 13) and ANCA-negative (n = 14) GPA patients, and age- and sex-matched HCs (n = 19). Bars represent the mean values ± SD. P-values were calculated using the nonparametric Mann-Whitney U-test.
Abdulahad et al. Arthritis Research & Therapy 2013 15:R70 doi:10.1186/ar4247