Therapeutic and combination effects of double-antiangiogenic protein in collagen-induced arthritis. (A) Therapeutic effect of double-antiangiogenic protein (DAAP). (B) Therapeutic effect of the combination of DAAP with etanercept. Following the development of clinical arthritis (average visual arthritis score of 2) on day 26 (arrow), collagen-induced arthritis mice were randomized to receive intraperitoneal injections of Fc, DAAP (25 mg/kg each every two days), etanercept (10 mg/kg every two days) or DAAP + etanercept (n = 8 or 9 mice for each group). Values are mean ± SE. *P < 0.05, **P < 0.01 vs. Fc.
Hah et al. Arthritis Research & Therapy 2013 15:R85 doi:10.1186/ar4265