How to regulate neutrophils in gout
Service de rhumatologie, Médecine physique et réhabilitation, Hôpital orthopédique, Avenue Pierre-Decker 4, CH-1011 Lausanne, Switzerland
Arthritis Research & Therapy 2013, 15:118 doi:10.1186/ar4316
See related research by Gagné et al. http://arthritis-research.com/content/15/4/R73Published: 25 September 2013
Most research in gout has concentrated on the proinflammatory mechanisms to explain the inflammation that is generated when leucocytes are in contact with monosodium urate crystals. However, the episodic nature of gout and the absence of inflammation even when crystals are present suggest that there are natural counter-regulatory mechanisms to limit the inflammatory response. Gagné and colleagues showed that myeloid inhibitory C-type lectin, a C-type lectin inhibitory receptor expressed on neutrophils, modulates monosodium urate-induced neutrophil responses in vitro.