Baseline HMGB1 levels in AAV patients with renal involvement, without renal involvement and controls. High-mobility group box 1 (HMGB1) levels at presentation in antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) patients with renal involvement and without renal involvement and in healthy controls (HC) (2.35 ± 1.48 ng/ml vs. 3.52 ± 2.41 ng/ml vs. 2.39 ± 1.09 ng/ml; P = 0.046). Using Dunnett's post-hoc test, nonrenal AAV patients had higher HMGB1 levels when compared with HC (P = 0.023) whereas no difference was found between patients with renal involvement and HC (P = 0.733).
de Souza et al. Arthritis Research & Therapy 2013 15:R104 doi:10.1186/ar4284