Immunohistochemical detection of CD148 in joints from mice with differing collagen-induced arthritis severities. Immunohistochemical staining for CD148 (A, C, E) and Mac-2 (B, D, F) protein expression (brown) was performed on joint tissue sections from CIA-immunized mice with score 0 (A, B), score 1 (C, D) and score 2 (E, F). All sections were counterstained with haematoxylin. AC, articular cartilage; BM, bone marrow; CIA, collagen-induced arthritis; J, joint space. Arrowhead denotes synovium. Magnification: x200; bar = 100 μm.
Dave et al. Arthritis Research & Therapy 2013 15:R108 doi:10.1186/ar4288