Nitric oxide (NO) donors differ from the amount of NO2- released. NO2- accumulation in supernatants of normal chondrocytes treated with different NO donors for 24 hours in standard culture conditions. The lines show the dose-dependent increase of NO accumulation in all cases. Values are the mean ± SD; n = 5. SNP, sodium nitroprusside; NOC-12, N-ethyl-2(1-ethyl-2 hydroxy-2-nitrosohydrazine.
de Andrés et al. Arthritis Research & Therapy 2013 15:R115 doi:10.1186/ar4295