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An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes

Dessislava Z Markova1, Christopher K Kepler13, Sankar Addya2, Hallie B Murray4, Alexander R Vaccaro13, Irving M Shapiro1, D Greg Anderson13, Todd J Albert13 and Makarand V Risbud1*

Author Affiliations

1 Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA

2 Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA

3 Department of Orthopaedic Surgery, Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA

4 Biomet Spine, Biomet Inc., 100 Interpace Parkway, Parsippany, NJ 07054, USA

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Arthritis Research & Therapy 2013, 15:R121  doi:10.1186/ar4301

Published: 16 September 2013

Additional files

Additional file 1:

Figure S1. Senescence-associated β-galactosidase staining of rat nucleus pulposus (NP) cells following treatment with TNF-α and IL-1β for 10 days. The result indicates that the number of SA-β-gal-positive NP cells is increased in the experimental (B) versus the control group (A).

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