Additional file 1.
Figure S1 lists kinases with more than 90% binding efficiency with RO9021 (1 μM) in the KinomeScan assay. Figure S2 shows the X-ray crystal structure of SYK with front view (A) and top view (B), showing the ATP binding site with RO9021 bound. Black dashes, hydrogen bonds; orange dashes, hydrophobic contacts to the Gly454/Pro455 region. Figure S3 shows the pharmacokinetics profile of single oral dose of RO9021 in mouse.
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Liao et al. Arthritis Research & Therapy 2013 15:R146 doi:10.1186/ar4329