Figure 2.

IL-17A enhances MCP-1, IL-8 and MMP-1 but not collagen production in HD and SSc fibroblasts. Dermal fibroblasts were cultured in the presence of 30 ng/ml of IL-17A. Protein levels are expressed as fold change relative to control condition (medium with no IL-17A, dotted line) assessed in 48-hour culture supernatants by ELISA (MCP-1, IL-8, MMP-1) and RIA (collagen). Each symbol represents a distinct individual and the horizontal lines depict the median. Significant differences relative to the control condition were assessed by the Wilcoxon signed-rank test.

ELISA: enzyme-linked immunosorbent assay; IL: interleukin; MCP-1: monocyte chemotactic protein-1; MMP-1: matrix metalloprotein-1; RIA : radio-immune assay.

Brembilla et al. Arthritis Research & Therapy 2013 15:R151   doi:10.1186/ar4334
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