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A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

David A Martin*, Melvin Churchill, Luis Felipe Flores-Suarez, Mario H Cardiel, Daniel Wallace, Richard Martin, Kristine Phillips, Jeffrey L Kaine, Hua Dong, David Salinger, Erin Stevens, Chris B Russell and James B Chung

Arthritis Research & Therapy 2013, 15:R164  doi:10.1186/ar4347