Degree of dependence of the major biological themes on genes located in Aec1 and Aec2 (mean ± SEM). Proportion of leading edge (LE) genes located in the disease-causing congenic loci Aec1 and Aec2/gene set (GS)/major biological theme within the same disease phase were compared using one-way analysis of variance and Tukey’s post hoc test. P-values <0.05 were considered significant (*P < 0.05, **P < 0.01, ***P < 0.0001). Columns represent the means, and error bars represent the standard errors of the mean. ECM, extracellular matrix; Igfr1, insulin-like growth factor receptor 1; Insr, insulin receptor.
Delaleu et al. Arthritis Research & Therapy 2013 15:R174 doi:10.1186/ar4362