Synovial fluid CD1c+ myeloid dendritic cells – the inflammatory picture emerges
The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, 37 Kent St, Woolloongabba, QLD 4102, Australia
Arthritis Research & Therapy 2013, 15:128 doi:10.1186/ar4420
See related research by Moret et al. http://arthritis-research.com/content/15/5/R155Published: 23 December 2013
Dendritic cells (DCs) comprise a heterogeneous group of antigen-presenting cells with many specialized functions, including essential constitutive roles in priming immune and autoimmune responses and in the maintenance of peripheral self-tolerance. At the interface of the innate and adaptive immune systems, they contribute considerably to the production of inflammatory and anti-inflammatory mediators with diverse functions. Emerging evidence suggests that the wide involvement of DCs in immunity and tolerance reflects the function of specialized DC subsets.