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Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

Tanya J Flynn1, Amanda Phipps-Green1, Jade E Hollis-Moffatt1, Marilyn E Merriman1, Ruth Topless1, Grant Montgomery2, Brett Chapman2, Lisa K Stamp3, Nicola Dalbeth4 and Tony R Merriman1*

Author Affiliations

1 Department of Biochemistry, University of Otago, 364 Leith St, North Dunedin 9016, New Zealand

2 Queensland Institute of Medical Research, Brisbane, Queensland, Australia

3 University of Otago, Christchurch, New Zealand

4 Department of Medicine, University of Auckland, Auckland, New Zealand

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Arthritis Research & Therapy 2013, 15:R220  doi:10.1186/ar4417

Published: 23 December 2013

Additional files

Additional file 1: Table S1:

Demographic and clinical characteristics of study participants. Table S2: Haplotype block summary. Table S3: Association of block-1 to −3 single nucleotide polymorphisms (SNPs) with serum urate in control individuals. Table S4: Interaction analysis between genotype, gout and co-morbid phenotypes.

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Additional file 2: Figure S1:

Intermarker linkage disequilibrium of single nucleotide polymorphisms (SNPs) previously associated with serum urate. Figure S2: Common linkage disequilbrium block haplotypes in European Caucasian and Han Chinese. Figure S3: Intermarker linkage disequilibrium between the 12 genoytped SNPs in European Caucasian and Han Chinese. Figure S4: Intermarker linkage disequilibrium between the 12 genoytped SNPs in New Zealand sample sets. Figure S5: Power calculations.

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