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Open Access Open Badges Commentary

How citrullination invaded rheumatoid arthritis research

Walther J van Venrooij* and Ger JM Pruijn

Author Affiliations

Department of Biomolecular Chemistry, Institute for Molecules and Materials and Nijmegen Centre for Molecular Life Sciences, Radboud University, PO Box 9101, NL-6500 HB, Nijmegen, The Netherlands

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Arthritis Research & Therapy 2014, 16:103  doi:10.1186/ar4458

Published: 29 January 2014


Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. In the first years after the initial publications, the focus was on the antibodies directed to citrullinated proteins. It is now realized that citrullinating enzymes and citrullinated proteins may have important roles in the maintenance of the inflammatory processes in the joints. There is also accumulating evidence for a direct role of citrullination in tissue destruction in the rheumatoid synovium. Here we will discuss the development and importance of anti-citrullinated protein antibodies in rheumatoid arthritis as well as recent findings implicating citrullination in the pathophysiology of rheumatoid arthritis.