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Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

Michiel Siebelt1*, Harald C Groen2, Stuart J Koelewijn2, Erik de Blois2, Marjan Sandker1, Jan H Waarsing1, Cristina Müller3, Gerjo JVM van Osch14, Marion de Jong2 and Harrie Weinans567

Author Affiliations

1 Department of Orthopedics, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands

2 Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

3 Center for Radiopharmaceutical Sciences PSI-ETH-USZ, Paul Scherrer Institute, Villigen-PSI, Villigen, Switzerland

4 Department of Otorhinolaryngology, Erasmus Medical Center, Rotterdam, The Netherlands

5 Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands

6 Department of Orthopaedics, UMC Utrecht, Utrecht, The Netherlands

7 Department of Rheumatology, UMC Utrecht, Utrecht, The Netherlands

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Arthritis Research & Therapy 2014, 16:R32  doi:10.1186/ar4461

Published: 29 January 2014

Additional files

Additional file 1: Figure S1:

Animal weight. Weight of all animals at 0, 6, and 12 weeks during the study. Nonrunning control animals (open circles) that received papain injections only, increased in weight throughout the study, whereas running animals (shaded boxes) that received papain injections started to increase in weight after the running protocol was completed at 6 weeks. Data points are nudged to prevent overlapping of the data.

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