Quantitative EPIC-μCT data depicting the therapeutic effect of μ-dHACM in MMT joints compared to controls. A) Average cartilage attenuation was significantly decreased in μ-dHACM treated MMT joints compared to saline injected MMT joints for the medial one-third tibial plateau. B) Average number of erosions was significantly decreased in μ-dHACM treated MMT joints compared to saline injected MMT joints. No lesions were observed in the μ-dHACM treated MMT joints. C) Average focal lesion volume in saline injected MMT joints.* p <0.05 and n =5. EPIC-μCT, equilibrium partitioning of an ionic contrast agent-micro computed tomography; MMT, medial meniscal transection; μ-dHACM, micronized dehydrated human amnion/chorion membrane.
Willett et al. Arthritis Research & Therapy 2014 16:R47 doi:10.1186/ar4476