Correlation of 25-OH vitamin D3 with SLEDAI scores and anti-dsDNA levels. Plasma 25-OH vitamin D3 levels of SLE patients correlated negatively with SLEDAI scores (A) and anti-dsDNA (B). SLE patients were categorized into two groups: treatment-naïve cases and patients under treatment. In both groups plasma levels of 25-OH vitamin D3 negatively correlated with SLEDAI scores (C and D). Modified SLEDAI scores (eliminating the anti-dsDNA score of 2) and its correlation with plasma levels of 25-OH vitamin D3 were analyzed. Similar to earlier observations, SLEDAI scores (-anti-dsDNA) negatively correlated with 25-OH vitamin D3 levels in both treatment-naïve cases (E) and treated patients (F). Dots represent individual samples. Correlation analysis was performed by Spearman’s correlation coefficient. A P value less than 0.05 was considered as significant. SLEDAI, systemic lupus erythematosus disease activity index; SLE, systemic lupus erythematosus; dsDNA, double-stranded DNA.
Mandal et al. Arthritis Research & Therapy 2014 16:R49 doi:10.1186/ar4479