Id1 expression is elevated in Wt, but not CXCR6−/− K/BxN serum-induced mice. Wild type (Wt) and CXCR6−/− mice were induced with K/BxN serum and joint tissue sections were immunostained for Id1. A) Day 12 Wt mice show clear expression of Id1 positive endothelial cells (ECs), whereas CXCR6−/− mice do not. B) The results are graphed and show that day 0 and 12 Wt mice have Id1 expressing endothelial progenitor cells (EPCs) in joint tissue, but Id1 positive cells were not detected in Day 12 K/BxN serum-induced CXCR6−/− mice (n = 10 sections from 10 mice for the Wt groups, and n = 10 sections from four mice in the CXCR6−/− group (400×)).
Isozaki et al. Arthritis Research & Therapy 2014 16:R68 doi:10.1186/ar4507