Additional file 9: Figure S6.
Association of pretreatment synovial gene-set scores with good versus poor European League Against Rheumatism (EULAR) response to anti-TNFα (infliximab) therapy at 16 weeks in the GSE21537 synovial expression dataset. Statistical significance for good compared with poor response for the level of each gene-set module was calculated based upon the t-statistic. Scaled gene-set scores for M2 alternatively activated monocytes (A) (P = 0.054), TNFα-stimulated fibroblast-like synoviocytes (B) (P = 0.08), and angiogenesis (C) (P = 0.02) marked with asterisk) are plotted against 16-week EULAR response.
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Dennis et al. Arthritis Research & Therapy 2014 16:R90 doi:10.1186/ar4555