Goldilocks, vitamin D and sarcoidosis
1 Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
2 1001 Holmes Building, Eden Ave, Cincinnati, OH 45267-0565, USA
Arthritis Research & Therapy 2014, 16:111 doi:10.1186/ar4568
See related research by Saidenberg-Kermanac’h et al., http://arthritis-research.com/content/16/2/R78Published: 23 May 2014
While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with bone fragility fractures in their sarcoidosis clinic. They found that a 25-(OH) vitamin D level between 10 and 20 ng/ml was associated with the lowest risk of bone fractures and paradoxically higher levels increased the risk of bone fractures. Using less vitamin D supplementation may simultaneously lower the risk for bone fracture and hypercalcemia in sarcoidosis.