Sample collection, cell growth, and multipotential stromal cell characterization. (A) Distal interphalangeal joint with osteoarthritis and an acute Heberden’s node (HN) with extrusion of gelatinous material and plane radiograph demonstrating visible joint space (arrowhead) indicating preservation of articular cartilage at clinical presentation. (B) Example of multipotential stromal cell-like colony grown from gelatinous cyst material and (C) population doublings of HN cells between passages 0 and 1 compared with synovial fluid (SF)- and iliac crest bone marrow-multipotential stromal cells. BM, bone marrow.
Baboolal et al. Arthritis Research & Therapy 2014 16:R119 doi:10.1186/ar4574