Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Open Badges Review

Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men

Lars Fugger1 and Arne Svejgaard2

Author Affiliations

1 Aarhus University Hospital, Skejby Sygehus, Denmark

2 Rigshospitalet, Copenhagen University Hospital, Denmark

For all author emails, please log on.

Arthritis Res 2000, 2:208-211  doi:10.1186/ar89

Published: 25 April 2000


Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.

human leukocyte antigen; rheumatoid arthritis; transgenic mice