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Fibroblast biology: Development and differentiation of synovial fibroblasts in arthritis

Jonathan CW Edwards

Author Affiliations

UCL Centre for Rheumatology, London, UK

Arthritis Res 2000, 2:344-347  doi:10.1186/ar110

Published: 8 June 2000


Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.

embryology; hyaluronan; synoviocyte; synovium; vascular cell adhesion molecule-1